Product Datasheet  
ETK (Phospho-Tyr566) Antibody  
Catalog Number: 11953  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P51813;
    NCBI Gene#: 660;
    NCBI Protein#: NP_001712.1
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Tyrosine566 (D-Q-Y(p)-V-S) derived from Human ETK.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:1000
  • other_names：  
  • BMX; BMX NON-receptor tyrosine kinase; Bone marrow kinase BMX; Epithelial and endothelial tyrosine kinase; NTK38
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of ETK only when phosphorylated at tyrosine 566.
  • Applications：  
  • WB
  • Background：  

  • Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility.

    Zhang R, et al. (2003) J Biol Chem 278, 51267-76
    Tsai YT, et al. (2000) Mol Cell Biol 20, 2043-54




 
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