Product Datasheet  
CDC25A (Phospho-Ser178) Antibody  
Catalog Number: 11948  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P30304;
    NCBI Gene#: 993;
    NCBI Protein#: NP_001780.2
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of serine 178(Q-N-S(p)-A-P) derived from Human CDC25A .
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:1000
  • other_names：  
  • CDC25M3; MPIP1; Dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of CDC25A only when phosphorylated at serine 178.
  • Applications：  
  • WB
  • Background：  

  • Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

    Chen MS, Ryan CE, Piwnica-Worms H (2003)Mol Cell Biol 23, 7488-97
    Hassepass I, Voit R, Hoffmann I (2003) J Biol Chem 278, 29824-9
    S?rensen CS, et al. (2003) Cancer Cell 3, 247-58




 
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