Product Datasheet  
MKP-1/2 (Phospho-Ser296/318) Antibody  
Catalog Number: 11947  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P28562/Q13115;
    NCBI Gene#: 1843/1846;
    NCBI Protein#: NP_004408.1/NP_001385.1
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of serine 296/318(I-I-S(p)-P-N) derived from Human MKP-1/2 .
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:1000
  • other_names：  
  • 3CH134; CL100; Dual specificity protein phosphatase 1; DUS1; DUSP1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of MKP-1/2 only when phosphorylated at serine 296/318.
  • Applications：  
  • WB
  • Background：  

  • Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

    Lin YW, Yang JL (2006) J Biol Chem 281, 915-26




 
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