Product Datasheet  
IKK- alpha/ beta (Phospho-Ser180/181) Antibody  
Catalog Number: 11930  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: O15111/O14920;
    NCBI Gene#: 1147;
    NCBI Protein#: NP_001269.3
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of serine 180/181 (C-T-S(p)-F-V) derived from Human IKK- alpha/ beta.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:1000
  • other_names：  
  • FLJ40509; I-kappa-B kinase; IKBKB; kinase beta; NFKBIKB
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of IKK- alpha/beta only when phosphorylated at serine 180/181.
  • Applications：  
  • WB
  • Background：  

  • Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.

    Hafeez BB, et al. (2008) Cancer Res 68, 8564-72
    Cahill CM, Rogers JT (2008) J Biol Chem 283, 25900-12
    Encinas M, et al. (2008)Cell Death Differ 15, 1510-21




 
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