Product Datasheet  
ATF1 (Phospho-Ser63) Antibody  
Catalog Number: 11913  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P18846;
    NCBI Gene#: 466;
    NCBI Protein#: NP_005162.1
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of serine 63(R-P-S(p)-Y-R) derived from Human ATF1 .
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:1000
  • other_names：  
  • ATF1; Activating transcription factor 1; Cyclic-AMP-dependent transcription factor ATF-1; TCR-ATF1; TREB36 protein
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of ATF1 only when phosphorylated at serine 63.
  • Applications：  
  • WB
  • Background：  

  • This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

    Mackenzie KF, et al. (2013) J Immunol 190, 565-77
    Dickinson RJ, et al. (2011) J Biol Chem 286, 38018-26
    Wang J, Zhou JY, Wu GS (2011) J Biol Chem 286, 22384-92




 
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