Product Datasheet  
FANCD2 (Phospho-Ser222) Antibody  
Catalog Number: 11965  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9BXW9;
    NCBI Gene#: 2177;
    NCBI Protein#: NP_001018125.1
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of serine 222 (G-D-S(p)-Q-H) derived from Human FANCD2.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:1000
  • other_names：  
  • DKFZp762A223; FA-D2; FA4; FACD; Fanconi anemia
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of FANCD2 only when phosphorylated at serine 222.
  • Applications：  
  • WB
  • Background：  

  • Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

    Ho GP, Margossian S, Taniguchi T, D'Andrea AD (2006)Mol Cell Biol 26, 7005-15. Nakanishi K, et al. (2002)Nat Cell Biol 4, 913-20. Taniguchi T, et al. (2002) Cell 109, 459-72 .




 
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