Product Datasheet  
Smad2 (Phospho-Ser465) Antibody  
Catalog Number: 11838  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q15796;
    NCBI Gene#: 4087;
    NCBI Protein#: NP_001003652.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 465(C-S-S(p)-M-S) derived from Human Smad2.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500~1:1000

  • other_names：  
  • hMAD-2; JV18; JV18-1; MAD; hSMAD2
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of Smad2 only when phosphorylated at serine 465.
  • Applications：  
  • WB
  • Background：  

  • Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a receptor-regulated SMAD (R-SMAD). May act as a tumor suppressor in colorectal carcinoma.

    Riggins G.J., Nat. Genet. 13:347-349(1996).
    Zhang Y., Nature 383:168-172(1996).
    Eppert K., Cell 86:543-552(1996).




 
© Signalway Biotechnology All Rights Reserved.