Product Datasheet  
GRIN2B (Phospho-Ser1303) Antibody  
Catalog Number: 11821  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q13224;
    NCBI Gene#: 2904;
    NCBI Protein#: NP_000825.2.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 1303(Q-H-S(p)-Y-D) derived from Human GRIN2B.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500~1:1000

  • other_names：  
  • GRIN2B; NMDE2; NME2; NR2B; NR3
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of GRIN2B only when phosphorylated at serine 1303.
  • Applications：  
  • WB
  • Background：  

  • N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.

    Adams S.L., Biochim. Biophys. Acta 1260:105-108(1995).
    Hess S.D., J. Pharmacol. Exp. Ther. 278:808-816(1996).
    Mandich P., Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.




 
© Signalway Biotechnology All Rights Reserved.