Product Datasheet  
Girdin (Phospho-Ser1417) Antibody  
Catalog Number: 11804  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q3V6T2;
    NCBI Gene#: 55704;
    NCBI Protein#: NP_060554.3.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 417(Q-K-S(p)-L-T) derived from Human Girdin .
  • reactivity：  
  • Hu Ms
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100

  • other_names：  
  • APE; GIV; GRDN; HkRP1; KIAA1212
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of Girdin only when phosphorylated at serine 1417.
  • Applications：  
  • IHC
  • Background：  

  • girdin IS a ubiquitously expressed actin binding protein that plays an important role in the formation of stress fibers and lamellipodia. Subsequent to phosphorylation by Akt, Girdin accumulates at the leading edge of migrating cells and appears to be crucial for the integrity of the actin cytoskeleton and for cell migration.

    Enomoto A., Dev. Cell 9:389-402(2005).
    Simpson F., Traffic 6:442-458(2005).
    Hillier L.W., Nature 434:724-731(2005).




 
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