Product Datasheet  
CDC25C (Phospho-Ser198) Antibody  
Catalog Number: 11790  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P30307;
    NCBI Gene#: 995;
    NCBI Protein#: NP_001274511.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 198(E-F-S(p)-L-K) derived from Human CDC25C.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100

  • other_names：  
  • CDC25M1; MPI1B; MPIP3; EC 3.1.3.48;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of CDC25C only when phosphorylated at serine 198.
  • Applications：  
  • IHC
  • Background：  

  • cdc25C is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

    Sadhu K., Proc. Natl. Acad. Sci. U.S.A. 87:5139-5143(1990).
    Bureik M., Int. J. Oncol. 17:1251-1258(2000).
    Wegener S., Eur. J. Cell Biol. 79:810-815(2000).




 
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