Product Datasheet  
Connexin 43 (Phospho-Tyr265) Antibody  
Catalog Number: 11767  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P17302;
    NCBI Gene#: 2697;
    NCBI Protein#: NP_000156.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Tyrosine 265(Q-K-Y(p)-A-Y) derived from Human Connexin 43.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500~1:1000

  • other_names：  
  • CX43; CXA1; CXN-43; GJA1;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • Connexin 43 antibody detects endogenous levels of Connexin 43 only when phosphorylated at Tyrosine 265
  • Applications：  
  • WB
  • Background：  

  • One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.

    Toshihiko Toyofuku, J. Biol. Chem., May 1998; 273: 12725.
    Toshihiko Toyofuku, J. Biol. Chem., Jan 1998; 273: 1519.
    Masayuki Shimada, Biol Reprod, Apr 2001; 64: 1255.
    Merry L. Lindsey, Circulation, Jun 2006; 113: 2919 - 2928.




 
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