Product Datasheet  
iNOS (Phospho-Tyr151) Antibody  
Catalog Number: 11766  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P35228;
    NCBI Gene#: 4843;
    NCBI Protein#: NP_000616.3.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 151(Q-Y-Y(p)-G-S) derived from Human iNOS .
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100

  • other_names：  
  • HEP-NOS; NOS2; inducible;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of Inos only when phosphorylated at tyrosine 151.
  • Applications：  
  • IHC
  • Background：  

  • Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.

    Geller D.A., Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495(1993).
    Sherman P.A., Biochemistry 32:11600-11605(1993).
    Charles I.G., Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423(1993).




 
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