Product Datasheet  
MYT1 (Phospho-Ser83) Antibody  
Catalog Number: 11745  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q99640;
    NCBI Gene#: 9088;
    NCBI Protein#: XP_006721039.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 83(R-V-S(p)-F-R) derived from Human MYT1.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100

  • other_names：  
  • PMYT1; PKMYT1; MYT1 kinase;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of MYT1 only when phosphorylated at serine 83.
  • Applications：  
  • IHC
  • Background：  

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

    Booher R.N., J. Biol. Chem. 272:22300-22306(1997).
    Liu F., Mol. Cell. Biol. 17:571-583(1997).
    Nousiainen M., Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).




 
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