Product Datasheet  
LATS1/2 (Phospho-Thr1079/1041) Antibody  
Catalog Number: 11736  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: O95835/Q9NRM7;
    NCBI Gene#: 9113/26524;
    NCBI Protein#: NP_004681.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T(p)-F-R) derived from Human LATS1/2 .
  • reactivity：  
  • Hu Ms
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100

  • other_names：  
  • WARTS; Large tumor suppressor 1; EC 2.7.11.1;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of LATS1/2 only when phosphorylated at threonine 1079/1041.
  • Applications：  
  • IHC
  • Background：  

  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding.

    Tao W., Nat. Genet. 21:177-181(1999).
    Nishiyama Y., FEBS Lett. 459:159-165(1999).
    The MGC Project Team, Genome Res. 14:2121-2127(2004).




 
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