Product Datasheet  
SHP-1 (Phospho-Tyr564) Antibody  
Catalog Number: 11721  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P29350;
    NCBI Gene#: 5777;
    NCBI Protein#: NP_002822.2.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 564(D-V-Y(p)-E-N) derived from Human SHP-1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:1000
    IHC dilution: 1:50-1:100
    IF dilution: 1:100-1:200
  • other_names：  
  • HCP; HCPH; PTN6; PTP1C; SHP1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of SHP-1 only when phosphorylated at tyrosine 564.
  • Applications：  
  • WB IHC IF
  • Background：  

  • Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

    Yi T., Mol. Cell. Biol. 12:836-846(1992).
    Shen S.H., Nature 352:736-739(1991).
    Plutzky J., Proc. Natl. Acad. Sci. U.S.A. 89:1123-1127(1992).




 
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