Product Datasheet  
Retinoblastoma (Phospho-Ser608) Antibody  
Catalog Number: 11720  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P06400;
    NCBI Gene#: 5925;
    NCBI Protein#: NP_000312.2.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 608(Y-L-S(p)-P-V) derived from Human Retinoblastoma.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100
    IF dilution: 1:100-1:200
  • other_names：  
  • P105-RB; PP105; PP110; RB1;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of Retinoblastoma only when phosphorylated at serine 608.
  • Applications：  
  • WB IHC IF
  • Background：  

  • Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.

    Lee W.-H., Nature 329:642-645(1987).
    Lee W.-H., Science 235:1394-1399(1987).
    Friend S.H., Proc. Natl. Acad. Sci. U.S.A. 84:9059-9063(1987).




 
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