Product Datasheet  
Nuclear Receptor NR4A1 (Phospho-Ser351) Antibody  
Catalog Number: 11704  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P22736;
    NCBI Gene#: 3164;
    NCBI Protein#: NP_002126.2.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine351(L-P-S(p)-K-P) derived from Human Nuclear Receptor NR4A1.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100

  • other_names：  
  • NGFIB; GFRP1; HMR; NR4A1; NAK1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of Nuclear Receptor NR4A1 only when phosphorylated at serine 351
  • Applications：  
  • IHC
  • Background：  

  • Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.

    Nakai A., Mol. Endocrinol. 4:1438-1443(1990).
    Chang C., J. Steroid Biochem. 34:391-395(1989).
    Bondy G.P., Cell Growth Differ. 2:203-208(1991)




 
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