Product Datasheet  
Bax (Phospho-Thr167) Antibody  
Catalog Number: 11680  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q07812;
    NCBI Gene#: 581;
    NCBI Protein#: NP_620116.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of threonine167 (P-G-T(p)-P-T) derived from Human Bax.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunofluorescence: 1:100~1:200

  • other_names：  
  • BAXA; Apoptosis regulator BAX; membrane isoform alpha; Bcl2-associated X protein;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of Bax only when phosphorylated at threonine 167.
  • Applications：  
  • IF
  • Background：  

  • Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

    Francesca Andriani. J Natl Cancer Inst, Sep 2001; 93: 1314 - 1324.
    H Martinez-Valdez. J. Exp. Med., Mar 1996; 183: 971.
    Joslyn K. Brunelle. J. Biol. Chem., Feb 2004; 279: 4305 - 4312.




 
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