Product Datasheet  
Estrogen Receptor-α (Phospho-Tyr537) Antibody  
Catalog Number: 11657  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P03372;
    NCBI Gene#: 2099;
    NCBI Protein#: NP_000116.2.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 537(P-L-Y(p)-D-L) derived from Human Estrogen Receptor-α.
  • reactivity：  
  • Hu Ms
  • appl_detail：  

  • Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100

  • other_names：  
  • ER; ESR; ESR1; ESTR; NR3A1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of ER-α only when phosphorylated at tyrosine 537.
  • Applications：  
  • WB IHC
  • Background：  

  • Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

    Sehime Temel, Endocrinology, Oct 2002; 143: 3974.
    Xin-Tian Zhang, AACR Meeting Abstracts, Apr 2005; 2005: 302.
    Suwit J. Somponpun, Am J Physiol Regulatory Integrative Comp Physiol, Sep 2004; 287: R661 - R669.
    Marcello Maggiolini, Cancer Res., Oct 1999;




 
© Signalway Biotechnology All Rights Reserved.