Product Datasheet  
p130 Cas (Phospho-Tyr410) Antibody  
Catalog Number: 11651  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P56945;
    NCBI Gene#: 9564;
    NCBI Protein#: NP_055382.2.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 410(G-V-Y(p)-A-V) derived from Human p130 Cas .
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100

  • other_names：  
  • BCAR1; CRKAS; CRK-ASSOCIATED SUBSTRATE;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of p130 Cas only when phosphorylated at tyrosine 410.
  • Applications：  
  • WB IHC
  • Background：  

  • Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

    Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 - 37535.
    Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 - H2863.
    Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 - 9189.
    Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 - 6




 
© Signalway Biotechnology All Rights Reserved.