Product Datasheet  
Synaptotagmin (Phospho-Thr202) Antibody  
Catalog Number: 11645  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P21579;
    NCBI Gene#: 6857;
    NCBI Protein#: NP_001129277.1
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of threonine 202(R-K-T(p)-L-N) derived from Human Synaptotagmin.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100

  • other_names：  
  • LAG; LAP18; STN1; Prosolin; stathmin
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of Synaptotagmin only when phosphorylated at threonine 202.
  • Applications：  
  • WB IHC
  • Background：  

  • The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse.

    E Carafoli, Crit. Rev. Biochem. Mol. Biol., Apr 2001; 36: 107.
    Gry Houeland, J Neurophysiol, Jan 2007; 97: 134 - 143.
    Christelle Carteron, J. Cell Sci., Mar 2006; 119: 898 - 909.
    Vladimir I. Slepnev, Science, Aug 1998; 281: 821.




 
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