Product Datasheet  
TrkA(Phospho-Tyr791) Antibody  
Catalog Number: 11326  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P04629
    NCBI Protein: NP_001007793.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D) derived from Human TrkA.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 140kd
    Western blotting: 1:500~1:1000
    Immunofluorescence: 1:100~1:200

  • other_names：  
  • High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth factor receptor; TRK; TRK1 transforming tyrosine kinase protein
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of TrkA only when phosphorylated at tyrosine 791.
  • Applications：  
  • WB IF
  • Background：  

  • Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

    Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17210-5.
    Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12270-5
    Inoue K, et al. J Biol Chem. 2007 Aug 17;282(33):24175-84




 
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