Product Datasheet  
SHP-1(Phospho-Tyr536) Antibody  
Catalog Number: 11318  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P29350
    NCBI Protein: NP_002822.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 536 (S-E-Y(p)-G-N) derived from Human SHP-1.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 68kd

    Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100
    Immunofluorescence: 1:100~1:200

     

  • other_names：  
  • 70Z-SHP; HCP; HCPH; Hematopoietic cell protein-tyrosine phosphatase; PTN6
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of SHP-1 only when phosphorylated at tyrosine 536.
  • Applications：  
  • WB IHC IF
  • Background：  

  • Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

    Migone TS, et al. (1998) Proc Natl Acad Sci USA; 95(7): 3845-3850.
    Timms JF, et al.(1998) Mol Cell Biol; 18(7): 3838-3850.
    Kanagasundaram V, et al. (1999) Mol Cell Biol; 19(6): 4079-4092.
    Hauck CR, et al. (1999) Infect Immun; 67(10): 5490-5494.




 
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