Product Datasheet  
Gab1(Phospho-Tyr627) Antibody  
Catalog Number: 11291  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q13480
    NCBI Protein: NP_002030.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 627 (V-E-Y(p)-L-D) derived from Human Gab1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 110kd
    Western blotting: 1:500~1:1000
    Immunofluorescence: 1:100~1:200
  • other_names：  
  • Growth factor receptor bound protein 2-associated protein 1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of Gab1 only when phosphorylated at tyrosine 627.
  • Applications：  
  • WB IF
  • Background：  
  • The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

    Anders Kallin, et al. (2004) J. Biol. Chem ; 279: 17897 - 17904.
    Hideto Kameda, et al. (2001) Cell Growth Differ ; 12: 307.
    Masaki Osawa, et al. (2002) J. Cell Biol ; 158: 773.



 
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