Product Datasheet  
SP1(Phospho-Thr739) Antibody  
Catalog Number: 11241  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P08047
    NCBI Protein: NP_612482.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around phosphorylation site of threonine 739 (T-A-T(p)-P-S) derived from human SP1
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 90kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • TSFP1; Sp1 transcription factor;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of SP1 only when phosphorylated at threonine 739.
  • Applications：  
  • WB
  • Background：  
  • Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-a G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

    Thiesen HJ,et al.(1990)Nucleic Acids Res.18(11):3203-9.
    Zutter MM,et al.(1997) Blood.90(2):678-89.
    Lou Z,et al.(2005)Cancer Res.65(3):1007-17



 
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