Product Datasheet  
BRCA1(Phospho-Ser988) Antibody  
Catalog Number: 11237  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P38398
    NCBI Protein: NP_009225.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around phosphorylation site of serine 988 (I-K-S(p)-F-V) derived from Human BRCA1.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 220kd
    Immunofluorescence: 1:100~1:200

  • other_names：  
  • RNF53
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of BRCA1 only when phosphorylated at serine 988.
  • Applications：  
  • IF
  • Background：  

  • The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

    Lin SY, et al. (2004) Proc Natl Acad Sci U S A, 101(17): 6484-6489
    Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718
    Beger C, et al. (2001) Proc Natl Acad Sci U S A; 98(1): 130-135
    Gardner K, et al. (2001) Breast Cancer Res; 3(1): 11-13
    Zheng L, et al. (2001) Proc Natl Acad Sci U S A; 98(17): 9587-9592




 
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