Product Datasheet  
HNF4a(Phospho-Ser304) Antibody  
Catalog Number: 11043  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P41235
    NCBI Protein: NP_000448.3
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around phosphorylation site of serine 304 (L-R-S(p)-Q-V)derived from Human HNF4a.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 52kd
    Western blotting: 1:1000
  • other_names：  
  • HNF4; TCF; MODY; HNF4A;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of HNF4a only when phosphorylated at serine 304.
  • Applications：  
  • WB
  • Background：  
  • The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes,including hepatocyte nuclear factor 1 a, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.

    Kritis A.A,et al.Gene 173:275-280(1996)
    Drewes T,et al.Mol. Cell. Biol. 16:925-931(1996)
    Yamagata K,et al.Nature 384:458-460(1996)
    Tanaka T,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases



 
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