Product Datasheet  
Phospho-I-kappa-B-alpha Antibody  
Catalog Number: 48325  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Goat
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P25963
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • A short amino acid sequence containing Ser 32 phosphorylated IκB-α of human origin.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000


    IP: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate)
  • other_names：  
  • I kappa B alpha antibody
    I-kappa-B-alpha antibody
    IkappaBalpha antibody
    IkB-alpha antibody
    IKBA antibody
    IKBA_HUMAN antibody
    IKBalpha antibody
    MAD 3 antibody
    MAD3 antibody
    Major histocompatibility complex enhan
  • Purification：  
  • Immunogen affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF
  • Background：  
  • On the basis of both functional and structural considerations, members of the IκB family of proteins can be divided into four groups. The first of these groups, IκB-α, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50-p65 NFκB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to κB sites, suggesting that the IκB-α family binds to the p65 subunit of p50-p65 heterocomplex through Ankyrin repeats. The second member of the IκB family is represented by a protein designated IκB-β. The third group of IκB proteins is represented by IκB-γ, a protein identical in sequence with the C-terminal domain of the p110 precursor of NFκB p50 and expressed predominantly in lymphoid cells. An additional IκB family member has been identified as IκB-ε, a protein which has several phosphorylated forms and is primarily found complexed with RelA and/or c-Rel.



 
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