Product Datasheet  
SHP-2(Phospho-Tyr580) Antibody  
Catalog Number: 11320  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q06124
    NCBI Protein: NP_002825.3
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 580 (R-V-Y(p)-E-N) derived from Human SHP-2.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 72kd
    Immunohistochemistry: 1:50~1:100
     

  • other_names：  
  • PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of SHP-2 only when phosphorylated at tyrosine 580.
  • Applications：  
  • WB IHC
  • Background：  

  • Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

    Ferjoux G, et al. (2003) Mol Biol Cell. 2003 ; 14(9): 3911-3928.
    Shi ZQ, et al. (2000) Mol Cell Biol ; 20(5): 1526-1536.
    Li C, Friedman JM. (1999) Proc Natl Acad Sci U S A ; 96(17): 9677-9682
    Manes S, et al. (1999) Mol Cell Biol ; 19(4): 3125-3135.
    Oh ES, et al. (1999) Mol Cell Biol; 19(4): 3205-3215.
     




 
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