Product Datasheet  
SIVA Antibody  
Catalog Number: 25397  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Chicken
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:O15304
    Gene ID:10572
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 16 amino acid peptide near the amino terminus of human SIVA.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • other_names：  
  • SIVA1, apoptosis-inducing factor, CD27-binding protein, CD27BP, SIVA-1, SIVA-2
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • Applications：  
  • ELISA WB
  • Background：  
  • SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.



 
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