Product Datasheet  
[KO Validated] β-Catenin Mouse mAb  
Catalog Number: 77553  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • P35222
  • Form of Antibody：  
  • Storage：  
  • Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% sodium azide,0.2% BSA,40% glycerol,pH7.4.
  • Immunogen：  
  • Recombinant protein of human β-Catenin.
  • reactivity：  
  • Human,Mouse,Rat
  • appl_detail：  
  • WB 1:500 - 1:2000
    IHC 1:50 - 1:200
    IF 1:50 - 1:200
    FC 1:50 - 1:200
  • other_names：  
  • CTNNB;MRD19;armadillo;beta Catenin;CTNNB1
  • Purification：  
  • Affinity purification
  • Specificity：  
  • Applications：  
  • WB,IHC,IF,FC
  • Background：  
  • The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]



 
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