Product Datasheet  
Ctip2 Antibody  
Catalog Number: 49390  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species:  
  • Amount:  
  • 100μgμg
  • Swiss-Prot No.:  
  • Swiss-Prot#:Q9C0K0
  • Form of Antibody:  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage:  
  • Store at -20˚C
  • Immunogen:  
  • recombinant protein
  • reactivity:  
  • Hu
  • appl_detail:  
  • WB: 1:1,000
    IHC: 1:50-1:200
    ICC: 1:50-1:200

    FC: 1:50-1:100

  • other_names:  
  • ATL1 alpha antibody
    ATL1 antibody
    ATL1 beta antibody
    ATL1 gamma antibody
    ATL1-delta antibody
    B cell CLL/lymphoma 11B/T cell receptor delta constant region fusion protein antibody
    B cell lymphoma/leukemia 11B antibody
    B-c
  • Purification:  
  • ProA affinity purified
  • Specificity:  
  • Applications:  
  • WB, ICC, IHC, FC
  • Background:  
  • Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.




 
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