Product Datasheet  
Angiotensin II Type 2 Receptor Antibody  
Catalog Number: 49054  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P50052
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  

  • WB: 1:1,000-1:2,000

     

  • other_names：  
  • AGTR 2 antibody
    Agtr2 antibody
    AGTR2_HUMAN antibody
    angiotensin II receptor type 2 antibody
    Angiotensin II type-2 receptor antibody
    Angiotensin receptor 2 antibody
    AT 2 antibody
    AT2 antibody
    ATGR 2 antibody
    ATG
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP
  • Background：  

  • Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLCγ is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.




 
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