Product Datasheet  
IKK alpha + IKK beta Antibody  
Catalog Number: 49034  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O14920
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  

  • WB: 1:1,000

    ICC: 1:100-1:500

  • other_names：  
  • CHUK antibody
    Conserved helix loop helix ubiquitous kinase antibody
    I kappa B kinase 1 antibody
    I kappa B kinase 2 antibody
    I Kappa B kinase alpha antibody
    I Kappa B kinase beta antibody
    IkB kinase alpha subunit antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC/IF, IP
  • Background：  

  • The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase a (IKKa), previously designated CHUK, interacts with IkB-a and specifically phosphorylates IkB-a on Ser 32 and 36, the sites that trigger its degradation. IKKa appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKa is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKa, IKKb and IKKg (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.




 
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