Product Datasheet  
Biglycan Antibody  
Catalog Number: 49829  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P21810
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB: 1:500-1:1000
    IHC: 1:50-1:200


    FC: 1:50-1:100
  • other_names：  
  • BGN antibody
    Biglycan antibody
    Biglycan proteoglycan antibody
    Bone/cartilage proteoglycan I antibody
    Dermatan sulphate proteoglycan I antibody
    DSPG1 antibody
    PG S1 antibody
    PG-S1 antibody
    PGI ant
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB,IHC,FC,IP
  • Background：  
  • Biglycan, a class I small leucine rich proteoglycan (SLRP) present in the extracellular matrix, influences bone cell differentiation and proliferation. Biglycan contains two chondroitin sulfate glucosaminoglycan (GAG) chains attached near its amino terminus, whereas a closely related SLRP, decorin, contains only one. Biglycan deficient specimens possess diminished capacity to produce bone cells precursors, a lessened response to TGFβ, reduced collagen synthesis, and increased apoptosis. Patients with rheumatoid arthritis express increased immunity to biglycan whereas osteoarthritis patients do not, suggesting that higher immunity to SLRPs may play a role in the pathogenesis of inflammatory rheumatic diseases.



 
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