Product Datasheet  
RBPJK Antibody  
Catalog Number: 49804  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q06330
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:1,000-5,000



  • other_names：  
  • AI843960 antibody
    AOS3 antibody
    CBF 1 antibody
    CBF-1 antibody
    CBF1 antibody
    csl antibody
    IGKJRB antibody
    IGKJRB1 antibody
    J kappa recombination signal binding protein antibody
    J kappa-
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB
  • Background：  
  • Recombination signal binding protein Jκ (RBP-Jκ), also designated KBF2 or CBF1, is the mammalian homolog of the Drosophila suppressor of hairless (Su(H)), a protein involved in the development of the peripheral nervous system. RBP-Jκ is ubiquitously expressed in mammalian tissues and is involved in the regulation of gene expression. RBP-Jκ has been shown to directly interact with the intercellular domain of the cell surface receptor Notch 1. Proteolytically cleaved Notch 1 translocates to the nucleus, where it binds DNA-bound RBP-Jκ and activates transcription of target genes. These genes include NFκB p52 and the Epstein-Barr virus (EBV) protein EBNA-2, both of which contain RBP-Jκ-binding sequences within their promoter regions.



 
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