Product Datasheet  
AKT1 Antibody  
Catalog Number: 48488  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P31749
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB: 1:2,000
    IHC: 1:100-1:200
    ICC: 1:100-1:200

    FC: 100-1:200
  • other_names：  
  • AKT 1 antibody
    AKT antibody
    AKT1 antibody
    AKT1_HUMAN antibody
    MGC99656 antibody
    PKB antibody
    PKB-ALPHA antibody
    PRKBA antibody
    Protein Kinase B Alpha antibody
    Protein kinase B antibody
    Proto-oncogene c-Akt antibody
    RAC Alpha antibody
    RAC antibody
    RAC-alpha serine/threonine-protein kinase antibody
    RAC-PK-alpha antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mice lacking Akt1 display a 25% reduction in body mass, indicating that Akt1 is critical for transmitting growth-promoting signals, most likely via the igf1 receptor. Mice lacking Akt1 are also resistant to cancer: They experience considerable delay in tumor growth initiated by the large T antigen or the Neuoncogene.



 
© Signalway Biotechnology All Rights Reserved.