Product Datasheet  
NKX2.2 Antibody  
Catalog Number: 48481  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:1,000



    FC: 1:100-1:200
  • other_names：  
  • Homeobox protein NK 2 homolog B antibody
    Homeobox protein NK-2 homolog B antibody
    Homeobox protein Nkx 2.2 antibody
    Homeobox protein Nkx-2.2 antibody
    NK 2 homolog B antibody
    NK2 homeobox 2 antibody
    NK2 transcription factor like protein B antibody
    NK2 transcription factor related locus 2 antibody
    NKX2 2 antibody
    NKX2-2 antibody
    NKX22 antibody
    NKX22_HUMAN antibody
    Nkx2b antibody
    tinman antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB,FC
  • Background：  
  • Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-2.1, Nkx-2.2 and Nkx-2.9. Specifically, the Nkx-2.2 protein is responsible for directing ventral neuronal patterning in response to graded Shh signaling. In the pancreas, Nkx-2.2 is expressed in a, b and pancreatic polypeptide (PP) cells, but not in d cells. Nkx-2.2 expression is required for differentiation of pancreatic b cells, which produce insulin. Homozygous null mutations of the Nkx-2.2 gene in mice lead to severe hyperglycemia and death shortly after birth, which suggests that Nkx-2.2 may be an important therapeutic target for pancreatic diseases, including diabetes and cancer.



 
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