Product Datasheet  
MPL Antibody  
Catalog Number: 48462  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P40238
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:1,000



    FC: 1:100-1:200
  • other_names：  
  • C MPL antibody
    CD110 antibody
    mpl antibody
    MPLV antibody
    Myeloproliferative leukemia protein antibody
    Myeloproliferative leukemia virus oncogene antibody
    Proto-oncogene c-Mpl antibody
    THCYT2 antibody
    Thrombopoietin receptor antibody
    TPO R antibody
    TPO-R antibody
    TPOR antibody
    TPOR_HUMAN antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, FC
  • Background：  
  • Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.



 
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