Product Datasheet  
NKX3A Antibody  
Catalog Number: 48454  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q99801
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:1000
    IHC: 1:50-1:200


    FC: 1:100-1:200
  • other_names：  
  • BAPX 2 antibody
    BAPX2 antibody
    Homeobox protein NK-3 homolog A antibody
    Homeobox protein Nkx 3.1 antibody
    Homeobox protein Nkx-3.1 antibody
    Homeobox protein Nkx3.1 antibody
    NK homeobox (Drosophila) family 3 A antibody
    NK homeobox family 3 A antibody
    NK homeobox, family 3, member A antibody
    NK3 homeobox 1 antibody
    NK3 transcription factor homolog A antibody
    NK3 transcription factor related locus 1 antibody
    NKX 3 antibody
    Nkx 3.1 antibody
    NKX 3A antibody
    NKX3 1 antibody
    NKX3 antibody
    Nkx3-1 antibody
    NKX3.1 antibody
    Nkx3.1, mouse, homolog of antibody
    NKX31_HUMAN antibody
    NKX3A antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IHC, FC
  • Background：  
  • The homeobox gene Nkx-3.1 is the human homolog of Drosophila bagpipe, which, in conjunction with tinman, determines cell fate in the dorsal mesoderm. In mammalian species, Nkx-3.1 is predominantly expressed in prostate, and it regulates prostate development in response to sonic hedgehog (Shh) signaling by exerting growth-suppressive and differentiating effects on prostatic epithelium. Nkx-3.1 is also expressed at lower levels in other tissues, including the heart and gut, in a Shh independent manner, where it plays a role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate and minor salivary glands. Nkx-3.1 preferentially binds the TAAGTA sequence, which has not been reported for any other NK class homeoprotein. The human Nkx-3.1 gene is located on chromosome 8q21, which frequently undergoes a loss of heterozygosity, and although Nkx-3.1 is not a tumor suppressor gene, it may be a useful marker for benign and malignant prostate epithelium.



 
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