Product Datasheet  
ANAPC11 Antibody  
Catalog Number: 48441  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9NYG5
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:1,000



    FC: 1:50-1:100
  • other_names：  
  • ANAPC 11 antibody
    ANAPC11 antibody
    Anaphase promoting complex subunit 11 (yeast APC11 homolog) antibody
    Anaphase promoting complex subunit 11 antibody
    Anaphase promoting complex subunit 11 homolog (yeast) antibody
    Anaphase promoting complex subunit 11 homolog antibody
    Anaphase-promoting complex subunit 11 antibody Apc 11 antibody
    Apc 11p antibody
    APC11 anaphase promoting complex subunit 11 homolog (yeast) antibody
    APC11 anaphase promoting complex subunit 11 homolog antibody
    APC11 antibody APC11_HUMAN antibody
    Apc11p antibody Cyclosome subunit 11 antibody
    Hepatocellular carcinoma associated RING finger protein antibody
    Hepatocellular carcinoma-associated RING finger protein antibody
    HSPC 214 antibody
    HSPC214 antibody MGC882 antibody
    Yeast APC 11 homolog antibody
    Yeast APC11 homolog antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, FC
  • Background：  
  • Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC's cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC; thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.



 
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