Product Datasheet  
KDM3A Antibody  
Catalog Number: 48411  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9Y4C1
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:2,000

    ICC: 1:50-1:200

    FC: 1:100-1:200
  • other_names：  
  • DKFZp686A24246 antibody
    DKFZp686P07111 antibody
    JHDM2A antibody
    JHMD2A antibody
    JmjC domain-containing histone demethylation protein 2A antibody
    JMJD1 antibody
    JMJD1A antibody
    Jumonji C domain containing histone demethylase 2A antibody
    Jumonji domain containing 1 antibody
    Jumonji domain containing 1A antibody
    Jumonji domain containing protein 1A antibody
    Jumonji domain-containing protein 1A antibody
    Kdm3a antibody
    KDM3A_HUMAN antibody
    KIAA0742 antibody
    Lysine (K) specific demethylase 3A antibody
    Lysine-specific demethylase 3A antibody
    Testis specific protein A antibody
    TSGA antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, FC
  • Background：  
  • JMJD1A (Jumonji domain containing 1A), also known as TSGA (testis-specific protein A), JMJD1, KDM3A, JHDM2A (JMJC domain-containing histone demethylation protein 2A) or JHMD2A, is a member of the JHDM2 histone demethylase family of proteins that is predominantly expressed in testis. Containing one JMJC domain and a C-terminal C2HC4 zinc finger, JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and a-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.



 
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