Product Datasheet  
KHDRBS2 Antibody  
Catalog Number: 48401  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q5VWX1
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB: 1:500-1:2,000
    IHC: 1:50-1:200


    FC: 1:50-1:100
  • other_names：  
  • KH domain containing, RNA binding, signal transduction associated protein 2 antibody
    6330586C16Rik antibody
    bA535F17.1 antibody
    FLJ38664 antibody
    hSLM 1 antibody
    hSLM-1 antibody
    KH domain containing, RNA binding, signal transduction associated 2 antibody
    KH domain-containing antibody
    KHDR2_HUMAN antibody
    khdrbs2 antibody
    MGC26664 antibody
    RNA-binding antibody
    Sam68 like mammalian protein 1 antibody
    Sam68-like mammalian protein 1 antibody
    signal transduction-associated protein 2 antibody
    SLM 1 antibody
    SLM-1 antibody
    SLM1 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IHC, FC
  • Background：  
  • RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.



 
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