Product Datasheet  
FBXL10 Antibody  
Catalog Number: 48385  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q8NHM5
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:1000



    FC: 1:50-1:200
  • other_names：  
  • [Histone-H3]-lysine-36 demethylase 1B antibody
    CXXC-type zinc finger protein 2 antibody
    CXXC2 antibody
    F box and leucine rich repeat protein 10 antibody
    F box protein FBL10 antibody
    F-box and leucine-rich repeat protein 10 antibody
    F-box protein FBL10 antibody
    F-box/LRR-repeat protein 10 antibody
    Fbl10 antibody
    FBXL10 antibody
    JEMMA (Jumonji domain EMSY interactor methyltransferase motif) protein antibody
    JHDM1B antibody
    JmjC domain-containing histone demethylation protein 1B antibody
    Jumonji C domain containing histone demethylase 1B antibody
    Jumonji domain-containing EMSY-interactor methyltransferase motif protein antibody
    kdm2b antibody
    KDM2B_HUMAN antibody
    Lysine (K) specific demethylase 2B antibody
    Lysine-specific demethylase 2B antibody
    PCCX2 antibody
    Protein containing CXXC domain 2 antibody
    Protein JEMMA antibody
    Protein-containing CXXC domain 2 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, FC
  • Background：  
  • FBXL10 (F-box and leucine-rich repeat protein 10), also known as Fbl10, CXXC2 (CXXC-type zinc finger protein 2), PCCX2, KDM2B, JEMMA (jumonji domain, EMSY-interactor, methyltransferase motif protein) or JHDM1B (jumonji C domain-containing histone demethylase 1B), is a nuclear protein that contains one F-box domain, a CXXC-type zinc finger, one JMJC domain, four leucine-rich repeats and one PHD-type zinc finger. FBXL10 belongs to the Fbls class of F-box proteins that contain leucine-rich repeats in addition to their F-box motif. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. In addition to its role in substrate recognition as a component of the E3 complex, FBXL10 functions as a dimethylation-specific demethylase, binding iron as a cofactor and demethylating lysine-36 of Histone H3. This suggests that FBXL10 plays a central role in the histone code.



 
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