Product Datasheet  
CELF1 Antibody  
Catalog Number: 48376  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q92879
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein within human CELF1 aa 1-180.
  • reactivity：  
  • Hu
  • appl_detail：  

  • IHC: 1:50-1:200


  • other_names：  
  • 50 kDa Nuclear polyadenylated RNA binding protein antibody
    50 kDa nuclear polyadenylated RNA-binding protein antibody
    Bruno like 2 antibody
    bruno like protein 2 antibody
    Bruno-like protein 2 antibody
    BRUNOL 2 antibody
    BRUNOL2 antibody
    CELF 1 antibody
    CELF-1 antibody
    celf1 antibody
    CELF1 CUGBP, Elav like family member 1 antibody
    CELF1_HUMAN antibody
    CUG BP and ETR 3 like factor 1 antibody
    CUG BP antibody
    CUG BP1 antibody
    CUG RNA binding protein antibody
    CUG triplet repeat RNA binding protein 1 antibody
    CUG triplet repeat RNA-binding protein 1 antibody
    CUG-BP antibody
    CUG-BP- and ETR-3-like factor 1 antibody
    CUG-BP1 antibody
    CUGBP 1 antibody
    CUGBP and ETR3 like factor 1 antibody
    CUGBP antibody
    CUGBP Elav like family member 1 antibody
    CUGBP Elav-like family member 1 antibody
    CUGBP1 antibody
    Cytidine uridine guanosine binding protein 1 antibody
    Deadenylation factor CUG BP antibody
    Deadenylation factor CUG-BP antibody
    Deadenylation factor CUGBP antibody
    EDEN BP antibody
    EDEN BP homolog antibody
    EDEN-BP antibody
    EDEN-BP homolog antibody
    embryo deadenylation element binding protein antibody
    embryo deadenylation element binding protein homolog antibody
    Embryo deadenylation element-binding protein homolog antibody
    hNab 50 antibody
    hNab50 antibody
    NAB 50 antibody
    NAB50 antibody
    NAPOR antibody
    Nuclear polyadenylated RNA binding protein 50 kD antibody
    Nuclear polyadenylated RNA binding protein antibody
    RNA binding protein BRUNOL 2 antibody
    RNA binding protein BRUNOL2 antibody
    RNA-binding protein BRUNOL-2 antibody
  • Purification：  
  • Protein affinity purified
  • Specificity：  
  • Applications：  
  • IHC,WB
  • Background：  
  • Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3'-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5' region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawl.



 
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