Product Datasheet  
xanthine dehydrogenase Antibody  
Catalog Number: 48373  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P47989
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Peptide
  • reactivity：  
  • Hu
  • appl_detail：  

  • IHC: 1:50-1:200


    FC: 1:50-1:100
  • other_names：  
  • Xanthine dehydrogenase antibody
    Xanthine dehydrogenase/oxidase antibody
    Xanthine oxidase antibody
    Xanthine oxidoreductase antibody
    XD antibody
    XDH antibody
    XDH_HUMAN antibody
    xdha antibody
    XO antibody
    xor antibody
  • Purification：  
  • ProG affinity purified
  • Specificity：  
  • Applications：  
  • IHC,FC
  • Background：  
  • The process of metabolizing purines to a common molecule known as xanthine is an essential process for the proper shuttling of uric acid. Xanthine oxidase is a flavoprotein enzyme that coordinates molybdenum and utilizes NAD+ as an electron acceptor to catalyze the oxidation of hypoxanthine to xanthine and then to uric acid. The predominant form of this enzyme is xanthine dehydrogenase, which is a homodimer that can be converted to xanthine oxidase by sulfhydryl oxidation or proteolytic modification. Xanthine oxidase is present in species ranging from bacteria to human and is ubiquitously expressed in mammalian tissues. In the oxidase form, this enzyme is coupled to the generation of free radicals. Individuals showing marked elevation of serum xanthine oxidase is suggestive of chronic liver disease and cholestasis, which is a condition defined by hepatic obstruction. Hepatic obstruction causes bile salts, the bile pigment bilirubin, and fats to accumulate in the blood stream instead of being eliminated normally. The clinical consequences of defects in xanthine oxidase range from mild to severe and even contribute to fatal disorders.



 
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