Product Datasheet  
CD130 Antibody  
Catalog Number: 48366  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P40189
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:2,000
    IHC: 1:50-1:200
    ICC: 1:50-1:200

  • other_names：  
  • CD130 antibody
    CD130 antigen antibody
    CDw130 antibody
    gp130 antibody
    GP130 RAPS antibody
    IL 6R beta antibody
    IL-6 receptor subunit beta antibody
    IL-6R subunit beta antibody
    IL-6R-beta antibody
    IL-6RB antibody
    IL6 ST antibody
    IL6RB_HUMAN antibody
    IL6ST antibody
    Interleukin 6 receptor subunit beta antibody
    Interleukin receptor beta chain antibody
    Interleukin-6 receptor subunit beta antibody
    Interleukin-6 signal transducer antibody
    Membrane glycoprotein 130 antibody
    Membrane glycoprotein gp130 antibody
    Oncostatin M receptor antibody
    Oncostatin M receptor alpha subunit antibody
    Oncostatin-M receptor subunit alpha antibody
  • Purification：  
  • ProG affinity purified
  • Specificity：  
  • Applications：  
  • WB,IHC,ICC
  • Background：  
  • Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition.



 
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