Product Datasheet  
E-Cadherin Antibody  
Catalog Number: 48355  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P09803
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu,Ms
  • appl_detail：  
  • WB: 1:500-1:1000
    IHC: 1:200
    ICC: 1:200

    FC: 1:50-1:100
  • other_names：  
  • Arc 1 antibody
    CADH1_HUMAN antibody
    Cadherin 1 antibody
    cadherin 1 type 1 E-cadherin antibody
    Cadherin1 antibody
    CAM 120/80 antibody
    CD 324 antibody
    CD324 antibody
    CD324 antigen antibody
    cdh1 antibody
    CDHE antibody
    E-Cad/CTF3 antibody
    E-cadherin antibody
    ECAD antibody
    Epithelial cadherin antibody
    epithelial calcium dependant adhesion protein antibody
    LCAM antibody
    Liver cell adhesion molecule antibody
    UVO antibody
    Uvomorulin antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin. The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This in turn may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to diagnose different kinds of breast cancer.



 
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