Product Datasheet  
SAPK/JNK (Phospho-Thr183/Tyr185) Antibody  
Catalog Number: 13331  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P45983
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Protein
  • reactivity：  
  • Hu, Ms, Rt, Hamster, S.cerevisiae
  • appl_detail：  
  • WB: 1:2,000

    ICC: 1:400
    IP: 1:250
    FC: 1:200
  • other_names：  
  • C Jun kinase 2 antibody
    c Jun N terminal kinase 1 antibody
    c Jun N terminal kinase 2 antibody
    c Jun N terminal kinase 3 antibody
    c-Jun N-terminal kinase 1 antibody
    JNK 46 antibody
    JNK 55 antibody
    JNK antibody
    JNK-46 antibody
    JNK1 antibody
    JNK1A2 antibody
    JNK2 antibody
    JNK21B1/2 antibody
    JNK2A antibody
    JNK2ALPHA antibody
    JNK2B antibody
    JNK2BETA antibody
    JNK3 alpha protein kinase antibody
    JNK3 antibody
    JNK3A antibody
    Jun kinase antibody
    JUN N terminal kinase antibody
    MAP kinase 10 antibody
    MAP kinase 8 antibody
    MAP kinase 9 antibody
    MAP kinase p49 3F12 antibody
    MAPK 10 antibody
    MAPK 8 antibody
    MAPK 9 antibody
    MAPK10 antibody
    mapk8 antibody
    MAPK9 antibody
    Mitogen activated protein kinase 10 antibody
    Mitogen activated protein kinase 8 antibody
    Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody
    Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody
    Mitogen activated protein kinase 9 antibody
    Mitogen-activated protein kinase 8 antibody
    MK08_HUMAN antibody
    p493F12 antibody
    p54a antibody
    p54aSAPK antibody
    p54bSAPK antibody
    PRKM10 antibody
    PRKM8 antibody
    PRKM9 antibody
    SAPK antibody
    SAPK(beta) antibody
    SAPK1 antibody
    SAPK1a antibody
    SAPK1b antibody
    SAPK1c antibody
    Stress activated protein kinase 1 antibody
    Stress activated protein kinase 1a antibody
    Stress activated protein kinase 1b antibody
    Stress activated protein kinase 1c antibody
    Stress activated protein kinase beta antibody
    Stress activated protein kinase JNK1 antibody
    Stress activated protein kinase JNK2 antibody
    Stress activated protein kinase JNK3 antibody
    Stress-activated protein kinase 1c antibody
    Stress-activated protein kinase JNK1 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF, ICC,FC
  • Background：  
  • The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, by growth factors and GPCR agonists (1-6). As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase (2). Stress signals are delivered to this cascade by small GTPases of the Rho family (Rac, Rho, cdc42) (3). Both Rac1 and cdc42 mediate the stimulation of MEKKs and MLKs (3). Alternatively, MKK4/7 can be activated in a GTPase-independent mechanism via stimulation of a germinal center kinase (GCK) family member (4). There are three SAPK/JNK genes each of which undergoes alternative splicing resulting in numerous isoforms (3). SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors (3,5)



 
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