Product Datasheet  
p70 S6 Kinase (Phospho-Ser 411) Antibody  
Catalog Number: 13329  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9UBS0
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • A sequence containing Ser 411 phosphorylated p70 S6 kinase α isoform 2 of human origin.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000
    IHC: 1:50-1:500

    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  • other_names：  
  • 70 kDa ribosomal protein S6 kinase 2 antibody
    EC 2.7.11.1 antibody
    KS6B2_HUMAN antibody
    p70 beta antibody
    p70 ribosomal S6 kinase beta antibody
    p70 S6 kinase beta antibody
    p70 S6K-beta antibody
    p70 S6KB antibody
    p70 S6Kbeta antibody
    p70(S6K) beta antibody
    p70-beta antibody
    p70-S6K 2 antibody
    P70S6K2 antibody
    p70S6Kb antibody
    Ribosomal protein S6 kinase 70kDa, polypeptide 2 antibody
    Ribosomal protein S6 kinase beta 2 antibody
    Ribosomal protein S6 kinase beta-2 antibody
    Rps6kb2 antibody
    S6 kinase related kinase antibody
    S6 kinase-related kinase antibody
    S6K beta 2 antibody
    S6K beta antibody
    S6K-beta antibody
    S6K-beta-2 antibody
    S6K2 antibody
    Serine/threonine protein kinase 14 beta antibody
    Serine/threonine-protein kinase 14B antibody
    SRK antibody
    STK14B antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF, IHC(P)
  • Background：  
  • In studies to elucidate key regulatory pathways in signal transduction, several protein serine/threonine (Ser/Thr) kinases have been identified. Included among such kinases are two distinct families of 40S ribosomal protein S6 Ser/Thr kinases present in somatic animal cells, designated p70 S6 kinase and p90 Rsk kinase. p90 Rsk kinase is maximally activated within minutes of addition of growth factors or phorbol ester to cultured cells followed by activation of p70 S6 kinase. Both enzymes are regulated by serine/threonine phosphorylation, suggesting that specific kinases may exist upstream in the signaling pathway that regulate these kinases. In fact, evidence suggests that one such family of activating enzymes includes the members of the ERK MAP kinase family. The ERK MAP kinases are, in turn, regulated by phosphorylation at threonine and tyrosine residues by a protein kinase designated MEK.



 
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